in association with the
AAPS Bioanalytical Focus Group

On

Wednesday, November 28, 2001 at 8:30AM to 4:30PM

at

Bucks County Sheraton, Langhorne, PA

(Location Information and Directions)
Register for an Event Here!!

_________________________________________________________

Will be Pleased to Present:

A Special Symposium

By

To provide an open forum for a discussion on the determination, interpretation and relevance of protein binding of pharmaceuticals.

___________________________________________________________________________

The Delaware Valley
DRUG METABOLISM DISCUSSION GROUP
In association with the AAPS Bioanalytical Focus Group

7:30-8:45	Registration and Coffee
8:45-9:00	Opening remarks by DMDG Chair
9:00-10:30	Morning Lecture Session : Stephen A. Wring, Section Head, Disposition Chemistry Mechanism and Extrapolation Technologies, GlaxoSmithKline, Inc. "In Vitro and in Silico Protein Binding Assays: Strategy for Timely Information During Drug Discovery and Development" Yanwen Qian, Team Leader, Worldwide Bioanalysis, DMPK, GlaxoSmithKline, Inc. "Validation of an Ultrafiltration Assay for the Determination of Unbound BRL- 10720 in Human Plasma" Scott Obach, Manager, Drug Metabolism Department, Pfizer Central Research "In Vitro Drug Metabolism Data: The Impact of non-Specific Binding Phenomena"
10:30-11:00	Break
11:00-11:30	Betty Ann Hoener, Professor of Biopharmaceutical Sciences, University of California at San Francisco "Changes in Plasma Protein Binding Have Little Clinical Relevance"
11:30-12:30	Discussion
12:30-1:30	Lunch
1:30-3:00	Afternoon Lecture Session : Jeffrey Barrett, Head Global Biopharmaceutics, Aventis Pharmaceuticals "Plasma Protein Binding of Anti-Viral Agents and HIV Therapy: Theory and Practice" Andrew Jayaraj, Associate Director & Head of Kinase Lead Evaluation, Vertex Pharmaceuticals Inc. "In Vitro Protein Binding of 14C-BG9928 in Rat, Dog, Monkey and Human Plasma and Protein Binding Interaction in Human Plasma" A case Study During Drug Development Kishor Wasan, Associate Professor and Chair, Division of Pharmaceutics & Biopharmaceutics, University of British Columbia "The Role of Plasma Lipoproteins in Modifying the Biological Activity of Hydrophobic Drugs"
3:00-3:30	Refreshment Break
3:30-4:00	Jerry Collins, Director, Laboratory of Clinical Pharmacology, FDA/CDER "Experimental and Conceptual Evaluation of Drug Binding: Interspecies, Intraspecies, and In Vitro - InVivo Comparisons"
4:00-5:00	Discussion [Refreshments will remain available]

REGISTRATION FEES AND RULES

• U.S. $150.00/ person for early registration before or on November 15,2001, and after November 15, 2001 U.S. $175.00/person.
• Check or Cash only. No Credit Card payment will be accepted.
• Please make checks payable to: DMDG
• Payment can be made on day of event (November 28,2001].
• No cancellations will be accepted after November 26, 2001.
• Advance payment should be mailed to Emily Young:
  

RESERVATIONS 
Must be made by November 23, 2001 in one of several ways:

• With your steering committee member.
• Call or fax Emily Young at [610] 326-9568 or
• Mail the Registration Form to Emily Young
  228 Maugers Mill Rd., Pottstown, PA 19464
• Or register on our Web Site at www.dvdmdg.org/dmdgreg.htm

Format will be classroom seating. Lunch will be a New York Style Deli Buffet

Register for an Event Here!!