The Delaware Valley

DRUG METABOLISM DISCUSSION GROUP

On

Thursday, November 7, 2002 at 7:30PM

at

Bucks County Sheraton in Langhorne, PA,

(Location Information and Directions)
Register for an Event Here!!

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Will be Pleased to Present:

F. Peter Guengerich, Ph. D.

Professor of Biochemistry & Director, Center in Molecular Toxicology

Vanderbilt University School of Medicine

On

"Recent Thoughts about Cytochrome P450: Ligand Specificity & the use of P450s in Drug Discovery"

Abstract

Cytochrome P450 (P450) enzymes are remarkably diverse oxygenation catalysts and are found throughout nature. Understanding their selectivity is challenging, and many efforts have been made in the context of predicting interactions with ligands. Defining the selectivity of a P450 in terms of a single residue may be difficult due to the global nature of proteins and their functions. A recent example comes from site-directed mutagenesis and other work with P450 2D6 and the roles of the acidic residues at positions 301 and 216. Although most of the interest regarding P450s in the pharmaceutical industry has been in the drug development aspects, P450s also offer potential in discovery, not only of drugs but also other useful chemicals. Potential applications range from use of P450s as drug targets to the use of randomly-generated mutants of P450s to produce libraries of new chemicals and drugs.

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A cocktail hour (Cash Bar) will begin at 5:30, followed by dinner at 6:30 PM. The registration fee for University Faculty and Students is $25, and $40 for all other attendees, including tax and gratuities. Dinner selections are: Salmon Sheraton, Chicken Picatta, or Roasted Vegatables over Pasta. Checks (made out to the DMDG) or Cash only. Credit cards cannot be accepted. Reservations must be made by November 4th and may be made in several ways:

  1. with your committee person
  2. calling or faxing Emily Young at (610) 326-9568
  3. on our website at www.dvdmdg.org or
  4. by mail to Emily Young, 228 Maugers Mill Rd., Pottstown, PA 19464

(e-mail addresses of the steering committee members can also be found at the site)

Cancellations cannot be honored after November 4th.

 


Register for an Event Here!!