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7:30 – 8:45 am

Registration and Continental Breakfast

8:45 – 9:00 am

Welcome and Introduction
Zhoupeng Zhang, (Merck, West Point, PA)

9:00 – 9:45 am

Covalent Binding – From 20th Century Liability to 21st Century Targeted Therapies
Greg Slatter (Kartos Therapeutics, Bellevue, WA)

9:45 – 10:30 am

An Integrated Strategy Utilizing Transcriptional Profiling to De-risk Bioactivation-Mediated Drug-Induced Liver Injury in Early Discovery
Kaushik Mitra (Merck, West Point, PA)

10:30 – 11:15 am

Coffee Break / Networking

11:15 – 12:00 pm

Necessity and sufficiency in drug-induced dermal toxicity: bioactivation, immunology, and host-dependent factors
Amy Sharma (Genentech, South San Francisco, CA)

12:00 – 1:15 pm

Lunch

1:15 – 1:20 pm

Afternoon Introduction
Peter Gorycki (GSK, Collegeville, PA)

1:20 – 2:05 pm

The Amine Functionality as a Structural Alert
Amit Kalgutkar (Pfizer, Boston, MA)

2:05 – 2:50 pm

Bioactivation of Herbal Constituents – What’s the Difference?
Bo Wen (GSK, Collegeville, PA)

2:50 – 3:05 pm

Coffee Break / Networking

3:05 – 3:50 pm

In Vitro Screening Approaches to Estimate Human Hepatic Responses to Xenobiotic Exposures
Stephen Ferguson (NIEHS, Durham, NC)

3:50 pm

Closing