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7:30 – 8:30 am

Registration and continental breakfast

8:30 – 8:40 am

Welcome and Introduction

8:40 – 9:25 am

Smart Trials: Moving from a Site-centric to Patient-centric Clinical Trials
Lisa Shipley (VP, Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck)

9:25 – 10:10 am

Changes in Drug Metabolism During Pregnancy, Insights from In Vitro, In Vivo, and In Silico Studies
Nina Isoherranen (Professor and Associate Chair, Dept. of Pharmaceutics, School of Pharmacy, University of Washington)

10:10 – 10:40 am

Coffee Break

10:40 – 11:00 am

Young researcher presentation: Hepatic FXR’s Protective Role Against Non-alcoholic Steatohepatitis Development in a High-fat Diet Induced Non-alcoholic Fatty Liver Disease Mouse Model
Laura Armstrong (Rutgers University)

11:00 – 11:45 am

Altered Hepatic Transport due to Liver Disease: Implications for Drug Development
Kim Brouwer (Professor and Associate Dean for Research and Graduate Education, University of North Carolina)

11:45 – 12:45 pm


12:45 – 1:05 pm

Young researcher presentation: Intracellular Unbound Drug Concentrations: Effect of Metabolism and Transport
Priyanka Kulkarni (Amgen)

1:05 – 1:50 pm

Assessing Pharmacokinetic Natural Product-Drug Interactions: Challenges and Opportunities
Mary Paine (Associate Professor, College of Pharmacy, Washington State University)

1:50 – 2:10 pm

Coffee Break

2:10 – 2:55 pm

Bioanalytical Approaches for Early Assessment of Metabolite Exposure in Human and Animals to Address MIST: Fundamentals, Strategy, and Perspectives
Hongying Gao (CEO and Founder, Innovo Bioanalysis)

2:55 – 3:40 pm

Evaluation of Transporter Abundance Variance and its Impact on IVIVE and Inter-species Comparison
Buyun Chen (Genentech)

3:40 pm


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