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For Every Drug Action there is Often an (Equal and Opposite) Drug-Drug Interaction
September 12, 2017 @ 8:00 am - 5:00 pm
Co-Chairs: Shen Hong (BMS), Peter J. Harvison (University of the Sciences)
7:30 – 8:30 am
Registration and Continental Breakfast
8:30 – 8:45 am
Welcome and Introduction
8:45 – 9:30 am
Drug-Drug Interactions: A Discovery and Lead Optimization Perspective
Punit Marathe
BMS
9:30 – 10:15 am
Prediction of pH-dependent Drug-drug Interactions with Acid Reducing Agents Using In Vitro and In Silico Methods
Cindy Xia
Takeda
10:15 – 10:45 am
Coffee / Networking Break
10:45 – 11:30 am
Circulating Drug Metabolites – Assessing Cytochrome P450 Inhibition by Metabolites in Ex Vivo Human Plasma
Heather Eng
Pfizer
11:30 – 12:15 pm
Nutrient Transporter-Mediated DDIs – Are We Ready for a Broad Recommendation for THTR2?
Yan Zhang
Incyte
12:15 – 1:15 pm
Lunch
1:15 – 2:00 pm
Evaluating Microdose Cocktails in the Context of Clinical Development
Aubrey Stoch
Merck
2:00 – 2:15 pm
Coffee / Networking Break
2:15 – 3:00 pm
DDI Predictions Using Endogenous Biomarkers
Yvonne Lin
University of Washington
3:00 – 3:45 pm
Evaluation of Endogenous Biomarkers of OATP Inhibition in Cynomolgus Monkeys and Humans
Hong Shen
BMS
3:45 pm
Closing