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Gut Reactions: An ADME-Centric View of the Gut Microbiome
September 17, 2019 @ 8:00 am - 4:00 pm
7:45 – 8:50 am
Registration
8:50 – 9:00 am
Introduction
9:00 – 9:45 am
Identifying Microbiome-Encoded Drug Metabolizing Enzymes
Andrew Goodman (Yale University)
9:45 – 10:30 am
Integrating Drug Metabolism via the Gut Microbiome into the Drug Discovery and Development Paradigm
Jason Boer (Incyte Pharmaceuticals)
10:30 – 10:45 am
Coffee Break
10:45 – 11:30 am
Functional Characterization of Drug Metabolizing Enzymes at the Host-Gut Microbiome Interface
Aaron Wright (Pacific Northwest National Laboratory and Washington State University)
11:30 – 12:15 pm
A Prevalent Operon from the Human Gut Microbiome is Responsible for the Inactivation of Fluoropyrimidine Anticancer Drugs
Peter Spanogiannopoulos (University of California San Francisco)
12:15 – 1:15 pm
Lunch
1:15 – 1:35 pm
A Multi-omic Approach to Understand the Development of the Gut-Liver Axis
Young investigator (Joseph Dempsey, University of Washington)
1:35 – 2:20 pm
Gut-Liver Axis and Environmental Chemical Exposures
Julia Cui (University of Washington)
2:20 – 2:35 pm
Coffee Break
2:35 – 3:20 pm
Microbiome Determinants of Arsenic Toxicity
Seth Walk (Montana State University)
3:20 – 4:05 pm
FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid
David Shen (University of Pennsylvania)