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Rozman Symposium: Bioactivation and Toxicity of Drugs
June 11, 2019 @ 8:00 am - 4:00 pm
7:30 – 8:45 am
Registration and Continental Breakfast
8:45 – 9:00 am
Welcome and Introduction
Zhoupeng Zhang, (Merck, West Point, PA)
9:00 – 9:45 am
Covalent Binding – From 20th Century Liability to 21st Century Targeted Therapies
Greg Slatter (Kartos Therapeutics, Bellevue, WA)
9:45 – 10:30 am
An Integrated Strategy Utilizing Transcriptional Profiling to De-risk Bioactivation-Mediated Drug-Induced Liver Injury in Early Discovery
Kaushik Mitra (Merck, West Point, PA)
10:30 – 11:15 am
Coffee Break / Networking
11:15 – 12:00 pm
Necessity and sufficiency in drug-induced dermal toxicity: bioactivation, immunology, and host-dependent factors
Amy Sharma (Genentech, South San Francisco, CA)
12:00 – 1:15 pm
Lunch
1:15 – 1:20 pm
Afternoon Introduction
Peter Gorycki (GSK, Collegeville, PA)
1:20 – 2:05 pm
The Amine Functionality as a Structural Alert
Amit Kalgutkar (Pfizer, Boston, MA)
2:05 – 2:50 pm
Bioactivation of Herbal Constituents – What’s the Difference?
Bo Wen (GSK, Collegeville, PA)
2:50 – 3:05 pm
Coffee Break / Networking
3:05 – 3:50 pm
In Vitro Screening Approaches to Estimate Human Hepatic Responses to Xenobiotic Exposures
Stephen Ferguson (NIEHS, Durham, NC)
3:50 pm
Closing